Can the gut microbiome explain the obesity–colorectal cance…

Can the gut microbiome explain the obesity–colorectal cancer link?

Emerging evidence suggests that the relationship between obesity and colorectal cancer extends beyond chronic inflammation and metabolic dysfunction to include microbial neurotransmitter signaling.

With the growing understanding of host–microbiome interactions that is reshaping disease biology, microbial metabolites and neurotransmitters are emerging as promising targets for precision prevention and future therapies.

#Obesity #ColorectalCancer #GutMicrobiome#PrecisionMedicine

Source

Guo, W., Sun, K., Wang, X. et al. Obesity-driven microbial GABA depletion promotes metabolic rewiring and colorectal cancer progression. Nat Commun 17, 7404 (2026). https://doi.org/10.1038/s41467-026-76079-1